Activity of Lysosomal Enzymes During Triple Combination Antihypertensive Treatment of Arterial Hypertension
Azayeva Nurana Rafail Gizi
Issue:
Volume 9, Issue 4, August 2023
Pages:
47-50
Received:
13 April 2023
Accepted:
21 June 2023
Published:
13 September 2023
Abstract: Summary: The aim of the study has been to study the biochemical parameters of blood, the activity of lysosomal enzymes in models of arterial hypertension (AH) and assess the effectiveness of three-component antihypertensive treatment. Research materials and methods: The experiment has included 23 rabbits of Chinchilla breed weighing 2.5-3.0kg, which the AH model has been created in. Of these, 8 rabbits which have not received antihypertensive therapy (AHT) have made up the control group. After 4 weeks of model creation, AHT has been started in 15 rabbits of the main group within 1 month. Over the course of 8 weeks, systolic blood pressure (SBP) and diastolic blood pressure (DBP) have been measured in rabbits using a veterinary electronic tonometer. Along with this, the level of creatinine, urea, residual nitrogen in the blood plasma, the activity of the enzymes lactate dehydrogenase (LDH) and the MB fraction of creatine phosphokinase (CPK-MB) have been determined, ECG studies have been performed. All rabbits have been prescribed valsartan/amlodipine/hydrochlorthiazide (80/12.5/5mg and 160/25/10mg), choosing an individual dose depending on blood pressure once a day per os. Results: During the study, along with an increase in blood pressure, an increase in the level of creatinine, residual nitrogen and urine in the blood plasma has been revealed when creating a model of hypertension, which has been accompanied by an increase during the month. A decrease in the activity of the enzyme LDH and CPK-MB has been also noted. After the therapy hold for 1 month, positive dynamics have been found both in the level of blood pressure and indicators of biochemical analysis. Since creatinine concentration has decreased by 28.5%, residual nitrogen – by 36%, urea – by 40%, LDH activity has increased by 30%, CPK-MB by 40%. Conclusion: Thus, along with an increase in blood pressure and indicators of biochemical analysis, a decrease in the activity of lysosomal enzymes is noted in AP models. An increase in the activity of the enzymes LDH and CPK-MB during the three-component AHT shows that the components of this combination affect various parts of the cellular metabolism.
Abstract: Summary: The aim of the study has been to study the biochemical parameters of blood, the activity of lysosomal enzymes in models of arterial hypertension (AH) and assess the effectiveness of three-component antihypertensive treatment. Research materials and methods: The experiment has included 23 rabbits of Chinchilla breed weighing 2.5-3.0kg, whic...
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Paraneoplastic Encephalitis Due to Anti-NMDA Receptor Antibodies in a Young Woman with Ovarian Teratoma
Gonzalez Manrique Guillermo,
Zabaleta Orozco Mario Alberto,
Claros Ortiz Katherine Viviana,
Cano Arias Luis Guillermo,
Velasco Hoyos Maria Fernanda,
Solano Vega Irina Isabel,
Lizcano Aros Jose Alfredo,
Luna Tavera Rina Liliana
Issue:
Volume 9, Issue 4, August 2023
Pages:
51-54
Received:
16 March 2023
Accepted:
1 April 2023
Published:
25 September 2023
Abstract: Anti-N-methyl D-aspartate receptor (NMDAR) encephalitis is a rare condition, often associated with neoplasms and characterized by neuropsychiatric symptoms and dysautonomia. Affecting approximately 0.01% of cancer patients, it is the second most frequent autoimmune encephalitis after acute disseminated encephalomyelitis, its clinical presentation is usually acute and severe, so prompt identification and treatment improve prognosis. We present the case of a 23-year-old female patient from a rural area of Caquetá, Colombia, previously healthy, who presented persistent psychotic symptoms of two weeks of evolution and was initially treated in a psychiatric unit where she evolved with systemic compromise. Finally, a diagnosis of paraneoplastic anti-NDMAR encephalitis was made. The patient received IV immunoglobulin G plus adjuvant systemic management with chemotherapy. She had complete resolution of her neuropsychiatric disorder and was asymptomatic when discharged. In conclusion, anti-NMDAR encephalitis is a condition with an underlying autoimmune mechanism, with production of autoantibodies mainly against the NR1 and NR2 subunits of NMDA receptors in the brain. These autoantibodies are produced in response to a breakdown of immune tolerance usually secondary to a neoplastic process, mostly ovarian teratoma, or infectious as in the case of herpes viral encephalitis. Despite its severe and potentially fatal nature, AE typically exhibits a positive response to treatment if a prompt diagnosis is established and management is initiated. However, it is acknowledged in some texts that there is still a gap in recognizing this entity, which encourages future valuable research.
Abstract: Anti-N-methyl D-aspartate receptor (NMDAR) encephalitis is a rare condition, often associated with neoplasms and characterized by neuropsychiatric symptoms and dysautonomia. Affecting approximately 0.01% of cancer patients, it is the second most frequent autoimmune encephalitis after acute disseminated encephalomyelitis, its clinical presentation i...
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